Puritans Pride Vitamin C and E 500 mg/400 IU with Rose Hips100 Softgels / Item #001261
<p style="padding: 0px; color: #333333; font-family: Arial, 'MS PGothic', Tahoma, sans-serif; font-size: 12px; line-height: 15px; text-align: center;"><img src="//gdetail.image-gmkt.com/951/716086280/2015/6/3883b46f-2325-4fe2-8bda-ea6e118f6f9f.jpg" ><br><br><img src="//gdetail.image-gmkt.com/951/716086280/2015/7/9498272f-d952-42ba-befb-430889df3914.jpg" ><br><br></p><ul id="bulletsright"><li>For over 40 years our mission has been to make the highest quality nutritional supplements available at the best value. </li><li>Headquartered in Long Island, N.Y. with our own state-of-the-art facilities located across the U.S., we manufacture over 1,200 high quality vitamins, minerals, and other nutritional supplements with ingredients sourced from all over the world.</li><li>As the manufacturer, we continue to offer the best prices in the industry by avoiding middle-man costs and passing the savings along to you. </li><li>We only use ingredients from suppliers that meet our stringent Quality Assurance Standards, as well as GMP food quality standards. Our products are subjected to countless quality tests and assays to verify purity and full potency. </li></ul><p style="text-align: center;"></p><br><p style="text-align: center;"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">Puritan's Pride<br>Vitamin C !#!amp!*! E 500 mg/400 IU with Rose Hips<br>100 Softgels / Item# 001261</span></p><br><br><p style="text-align: center;"><span style="font-size: 14pt;"><img src="//gdetail.image-gmkt.com/951/716086280/2020/9/d23e6e54-03aa-4aab-a323-cb6adf55f48e.jpg" width="300" height="536" onerror="this.src='https://gdetail.image-gmkt.com/951/716086280/2020/9/d23e6e54-03aa-4aab-a323-cb6adf55f48e.jpg'; $(this).attr('onerror','');" ></span></p><p style="text-align: center;"></p><p style="text-align: center;"><span style="font-size: 18pt;"><strong>Made in USA</strong></span><br><br></p><div class="product-description rte" itemprop="description"><div class="container-product-img"><ul><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Vitamin E helps promote healthy skin.**</span></li><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Vitamin C contains collagen formation**</span></li><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Vitamins A !#!amp!*! E helps improve immune system.**</span></li></ul></div><p style="text-align: left;"> <br> <br><br></p><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Imagine … two powerful antioxidants in one softgel! This high-quality supplement delivers 500 mg of Vitamin C and 400 I.U. of Vitamin E. Both vitamins play important roles in supporting cardiovascular, antioxidant, and immune system health.** In addition, Vitamin C is involved in collagen formation, which is important for healthy nails, skin, hair and connective tissue.**</span></p><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Individual Results May Vary.</span></p><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>No Artificial Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast.<br> <br> </span></p><div class="product-content-section-immune-2-info"><h2 class="omnes-blue-md pb-20" style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 24pt;"><strong>Vitamin C for Immune Health</strong></span></h2><h4 class="text-bold" style="text-align: left;"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">BARRIER FUNCTION<br> <br><br></span></strong></h4><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">The body’s first line of defense, the physical barrier created by the skin, relies on vitamin C. Vitamin C is necessary for the production of collagen, an important type of connective tissue.** Collagen creates the structural framework of the skin to promote skin integrity, helping to effectively keep unwanted substances from entering the body. <br><br></span></p><h4 class="text-bold" style="text-align: left;"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">ANTIOXIDANT HEALTH<br> <br><br></span></strong></h4><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Vitamin C’s important role in immune health does not stop at the surface.** During the initial stages of the immune response, white blood cells of the innate immune system start the inflammatory response as one means of dealing with unwelcomed visitors. In a state of inflammation, an abundance of free radicals can be produced.</span></p><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br><br>Free radicals are unstable compounds that can interfere with a normal cell’s ability to function optimally. Free radicals cannot differentiate between your own healthy cells and the target of your immune system so they can end up damaging your own cells. Vitamin C is a powerful antioxidant that helps to fight free radicals.** It also helps to regenerate other antioxidants like vitamin E to their active state to maintain antioxidant support.**<br><br></span></p><h4 class="text-bold" style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br><strong>WHITE BLOOD CELL SUPPORT<br> <br><br></strong></span></h4><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">In addition to supporting skin integrity and antioxidant health, vitamin C is essential for the optimal functioning of white blood cells.** During an immune response, white blood cells go through a process of rapid division and multiplication. Vitamin C supports the production of the important B and T cells of the adaptive immune response.** It also helps special types of cells of the innate immune system called phagocytes do their job, engulfing unwanted compounds.**</span></p></div><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br><br></span></p><div class="container-fluid product-content-section-immune-3 text-center pt-40 pb-40" style="text-align: left;"><div class="row"><div class="container text-white"><div class="row"><div class="pl-15 pr-15"><h2 class="omnes-blue-md pb-20 text-white"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><img src="https://cdn-fsly.yottaa.net/5a708bdc2bb0ac612489fe30/53ab8c90f55201355cf20a3ba3fac80a.yottaa.net/v~4b.aa/pp/vf/puritanspride/pdp/product_detail_enhanced/immune/icon_lightbulb.png?yocs=D_G_" alt="icon lightbulb" data-yo-delaytype="lazy" data-yo-src="https://cdn-fsly.yottaa.net/5a708bdc2bb0ac612489fe30/53ab8c90f55201355cf20a3ba3fac80a.yottaa.net/v~4b.aa/pp/vf/puritanspride/pdp/product_detail_enhanced/immune/icon_lightbulb.png?yocs=D_G_" data-yo-loaded="true"><span style="font-size: 18pt;"> Why Supplement with Vitamin C?</span></span></h2><h4 class="text-bold text-left pb-20"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">The Recommended Dietary Allowance (RDA) for adults is between 75-90 mg per day depending on gender, but some experts recommend a daily intake of at least 200 mg/day for healthy individuals.<sup>9</sup></span></h4><p class="text-left"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Unlike most other animals, humans cannot synthesize their own vitamin C so it must be obtained from dietary sources. As a water soluble vitamin, vitamin C dissolves easily in water but cannot be readily store in the body. This means adequate amounts of vitamin C should be consumed every day.</span></p><p class="text-left"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Vitamin C is found in foods such as citrus fruits, strawberries, cantaloupes, raw vegetables and potatoes. Unfortunately, in today’s busy world, many of us do not consume as many fruits and vegetables as we should. National survey data indicates Americans are not meeting the recommendations for daily fruit and vegetable intake, resulting in a significant prevalence of about 40% of Americans with inadequate dietary intake of vitamin C.<sup>8</sup> Furthermore, vitamin C is sensitive to heat so boiling and other cooking methods can deplete the natural vitamin C content of foods.</span></p><p class="text-left"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Daily intake of 200 mg supports respiratory health.<sup>**</sup> Note that while this amount provides adequate support for most healthy individuals, actively multiplying and dividing white blood cells may have even higher requirements of vitamin C.<sup>**<br><br></sup></span></p><div class="pdp-references mb-30 text-left"><ul><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> </span></li><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">References</span></li><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">8. Fulgoni VL, et al. J Nutr. 2011 Oct;141(10):1847-54.</span></li><li><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">9. Calder PC, et al. Nutrients. 2020;12(4):1181.</span></li></ul></div></div></div></div></div></div><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br><br></span></p></div><div class="col-xs-10 col-xs-push-1 col-md-6 col-md-push-6 product-content-section-immune-4-content" style="text-align: left;"><h3 class="omnes-blue-md pb-10 pt-10"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">What is the Immune System?<br> <br><br></span></strong></h3><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Every day, your body is bombarded by foreign substances from the outside world. Credit card pin pads, bathroom faucets, cell phones, literally everything you touch is covered in tiny microorganisms. Not all microorganisms are bad, in fact there are trillions of bacteria found in and on the human body which cause no harm, or in some cases are even beneficial to human health.</span></p><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><br> <br>However, there are also less favorable microorganisms found in the environment. The main function of your immune system is to protect you from external threats and keep you healthy.</span></p><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Think of your immune system as your body’s security team, trained to recognize and remove any threats while protecting your body’s peaceful residents.</span></p><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>The first line of defense is to restrict the entry of unwanted foreign materials. The skin creates an excellent physical barrier but unwanted guests may still be inhaled or ingested. The acidity of stomach acid, mucosal membranes, and the presence of antibodies in saliva and tears all further help to prevent the entry of these substances into the body.</span><br><br><br></p><div class="col-xs-12"><h2 class="omnes-blue-md pb-40"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">Four Main Functions of the Immune System</span></strong></h2></div><div class="col-md-3"> <br><br><div class="omnes-md icon-callout-header icon-callout-header-red pt-10 pb-10"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Exclusion Barrier</span></strong></div><p class="pb-10"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Physical barriers keep pathogens from entering the body – e.g. skin, mucosa layer of GI tract, antibodies in saliva, pH of stomach</span></p></div><div class="col-md-3"> <br><br><div class="omnes-md icon-callout-header icon-callout-header-green pt-10 pb-10"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Recognition</span></strong></div><p class="pb-10"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">If substances get through the exclusion barrier, they need to be recognized as non-self</span></p></div><div class="col-md-3"> <br><br><div class="omnes-md icon-callout-header icon-callout-header-orange pt-10 pb-10"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Elimination</span></strong></div><p class="pb-10"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Elimination only of unwanted threats, not self or friendly bacteria</span></p></div><div class="col-md-3"> <br><br><div class="omnes-md icon-callout-header icon-callout-header-lightblue pt-10 pb-10"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Memory</span></strong></div><p class="pb-10"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Immune memories allow for fast recognition and elimination of repeat offenders</span><br> <br><br></p><div class="col-xs-12"><h2 class="omnes-blue-md pb-20"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">Your First Line of Defense: Innate Immune System <br><br></span></h2></div><div class="col-md-6 text-left"><p class="pl-15 pr-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.</span></p></div><div class="col-md-6 text-left"><p class="pl-15 pr-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.<sup>1</sup> Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.</span></p></div></div></div><br class="clearfloat"><div class="col-xs-12" style="text-align: left;"><h2 class="omnes-blue-md pb-20"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;"> <br><strong>Your Second Line of Defense: Adaptive Immune Response</strong></span></h2></div><div class="col-md-6 text-left" style="text-align: left;"><p class="pl-15 pr-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>If a non-beneficial microorganism is able to pass through your body’s first line of defense, it must be recognized by your immune system. Recognition is an important feature of your patrolling security team. Without it, your immune system would attack non-threatening foreign substances and even your own cells. Undesirable substances are recognized by white blood cells that send messages akin to sounding an alarm, drawing more white blood cells to the area. There are many different types of white blood cells, also called leukocytes, that all work together to orchestrate the appropriate immune response. The elements of the immune system discussed thus far are all considered part of the innate response.</span></p></div><div class="col-md-6 text-left" style="text-align: left;"><p class="pl-15 pr-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"> <br>Characterized as being fast and non-specific, the innate immune system responds within minutes or hours.<sup>1</sup> Once the innate immune system has identified a threat, it seeks to eliminate it. The various white blood cells of the innate immune system each fight these threats in their own unique ways. Some will trigger an inflammatory response while others will deal with it directly by engulfing it or releasing toxic chemicals. Since the innate immune response is non-specific, the response is generally the same regardless of whether the same pathogen is encountered numerous times.</span><br><br></p><div class="col-xs-12 "><h2 class="text-bold pb-20 text-center-xs"><strong><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">Factors that Affect Immune Health<br> <br><br></span></strong></h2><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Your immune system is always patrolling your body to keep you at your best, but you need to keep your immune system healthy too. Every day you need to provide your immune system with the energy and nutrients it needs to function optimally.</span></p></div><div class="col-sm-6 col-md-4 immune-img-container"> <br><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">AGE</span>:</strong> The immune response starts to weaken around age 60 and continues to weaken with age.<sup>2</sup></span></p></div><div class="col-sm-6 col-md-4 immune-img-container"> <br><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">SLEEP</span>:</strong> Important immune proteins called cytokines are released while we sleep. Sleep deprivation leads to decreased immune function as well as increased recovery times.<sup>3</sup></span></p></div><div class="col-sm-6 col-md-4 immune-img-container"><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">STRESS</span>:</strong> Both physical and emotional stress can negatively impact the immune system. The stress hormone cortisol has been shown to decrease white blood cell numbers.<sup>7</sup></span></p></div><div class="col-sm-6 col-md-4 immune-img-container"><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">SMOKING</span>::</strong> Smoking causes dysfunction of white blood cells involved in both innate and adaptive immunity.<sup>5</sup> It is estimated that 1.1 billion people in the world are smokers.<sup>6</sup></span></p></div><div class="col-sm-6 col-md-4 immune-img-container"><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">PHYSCIAL ACTIVITY</span>:</strong> Regular moderate-intensity exercise achieved on a near-daily basis is associated with better immune health with age. More than 80% of U.S. adults are not meeting guidelines for both aerobic and muscle-strengthening activities.<sup>4</sup></span></p></div><div class="col-sm-6 col-md-4 immune-img-container"><br><p class="pt-15 pb-15"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;"><strong><span style="font-size: 18pt;">NUTRITION</span>:</strong> The immune system needs proper nutrients to function optimally. There are a number of vitamins, minerals and other nutrients that are widely recognized for their role in supporting immune health.<sup>**</sup></span></p></div></div><p style="text-align: left;"> <br><br><br></p><div class="container product-content-section-immune-9 mt-40" style="text-align: left;"><div class="row"><div class="container"><div class="col-xs-12"><h5 class="omnes-blue-md"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;">Myth: All immune support supplements work the same way.</span></h5><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">Because the immune system is such a complex system, there is not a one-size-fits-all approach to supporting immune health. The various different types of white blood cells, immune proteins, and tissues and organs all have different nutrient requirements. Taking a single nutrient for immune health may assist in supporting one of these aspects of immune health, but if you are lacking other nutrients in your diet, then you may be falling short in getting total immune support.<sup>**</sup></span></p><h5 class="omnes-blue-md"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;"> <br>Myth: The immune system is stronger in the summer.</span></h5><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">The immune system works year-round to keep you healthy no matter what the season. Depending on location and lifestyle factors, vitamin D status may be higher in the summer to better support certain aspects of immune health.<sup>**</sup> Winter weather conditions such as dry air may also affect immune health. It is still important to support your immune health every day throughout the year for optimal functioning.</span></p><h5 class="omnes-blue-md"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;"> <br>FAQ: How can you boost your immune system?</span></h5><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">The immune system should not be "boosted” beyond normal, optimal functioning. In fact, many autoimmune diseases are characterized by an overactive immune system that starts attacking its own cells. There are however lifestyle changes that you can make to help support normal functioning of the immune system. These include getting adequate sleep, engaging in regular physical activity, managing stress, eating a balanced diet and getting adequate amounts of immune supporting nutrients.</span></p><h5 class="omnes-blue-md"><span style="font-family: arial, helvetica, sans-serif; font-size: 18pt;"> <br>FAQ: Where is the immune system?</span></h5><p><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">The immune system is a complex network of organs, cells, tissues and proteins found throughout the body. It includes the thymus, spleen, bone marrow, skin, tonsils and Peyer’s patches in the intestines. The lymph system allows white blood cells of the immune system to patrol the entire body looking for foreign invaders.</span></p></div></div></div></div><div class="container"><div class="row"><div class="col-xs-12 pdp-references mb-30"><p style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">References:</span></p><ul><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">1. Gombart AF, Pierre A, Maggini S. Nutrients. 2020;12(1):236.</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">2. Pawelec G, Larbi A, Derhovanessian E. J Comp Pathol. 2010;142 Suppl 1:S39-S44.</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">3. Krueger JM, Majde JA, Rector DM. Cytokines in Immune Function and Sleep Regulation.; 2011. doi:10.1016/B978-0-444-52006-7.00015-0</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">4. President’s Council on Sports, Fitness !#!amp!*! Nutrition. U.S. Department of Health and Human Services Website. Updated January 26, 2017. Accessed July 2, 2020.https://www.hhs.gov/fitness/resource-center/facts-and-statistics/index.html</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">5. Qiu F, Liang CL, Liu H, et al. Oncotarget. 2017;8(1):268-284.</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">6. Tobacco.https://www.who.int/news-room/fact-sheets/detail/tobacco. Accessed March 24, 2020.</span></li><li style="text-align: left;"><span style="font-family: arial, helvetica, sans-serif; font-size: 14pt;">7. McGregor BA, Murphy KM, Albano DL, Ceballos RM. Stress. 2016;19(2):185-191.</span></li></ul></div></div></div><p style="text-align: center;"><br><br><span style="font-size: 14pt;"><img src="//gdetail.image-gmkt.com/951/716086280/2015/7/9e1aa7df-cdbc-4b31-9245-5271aca9b26f.jpg" ></span></p>